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205 reviews

5 Reasons Nattokinase Is Used to Support Heart Health

On a heart health journey? Here's why adding Toku Flow to your routine can make a real difference.

1. Hearth Health Backed By Clinical Research

Nattokinase has been examined in long-term clinical research focused on cardiovascular structure and blood flow related markers.

In a 12-month study involving over 1,000 participants, when taking at 10,800 FU daily, nattokinase supplementation was associated with a:

  • 39.1% improvement in coronary plaque health (measured by coronary plaque score)

  • 25% improvement in carotid artery flexibility (measured by CCA-IMT)

  • 17.6% reduction in total cholesterol

  • 16.5% reduction in triglycerides


Rather than targeting symptoms, this research explored how nattokinase supports foundational cardiovascular processes over time.

2. Nattokinase Goes Beyond Just Cholesterol

Cholesterol is only one part of the heart health picture.

A more complete cardiovascular assessment often includes markers related to:

  • ApoB, which reflects the number of circulating lipoprotein particles

  • Blood viscosity and flow characteristics

  • Vascular inflammation and endothelial function

  • Overall circulatory efficiency


Nattokinase has been studied for its role in supporting systems connected to these broader processes, which is why it’s often discussed as part of a more holistic heart health approach rather than a cholesterol-focused one.

A Clinically Relevant Dose of Nattokinase

Not all nattokinase is created equal. In fact, many brands on the market are underdosed and not third party tested. Explore a high-potency nattokinase at 10,800 FU that is third party tested, free of fillers, and soy free.

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3. A Natural, Food-Derived Approach to Heart Health

Nattokinase was originally discovered in natto, a fermented Japanese food that has been part of traditional diets for over a thousand years.

Populations with regular natto consumption have long been associated with strong cardiovascular health, which led researchers to identify nattokinase as one of its most compelling enzymes.

Toku Flow offers a modern, convenient way to incorporate this Japanese enzyme into a daily routine without needing to consume natto itself.

Why this matters:
Some of the most trusted heart-supporting ingredients come from traditional foods, not synthetic trends.

4. Supports the Systems That Influence Blood Pressure

Blood pressure is shaped by multiple factors, including circulation, vascular tone, and arterial flexibility.


Nattokinase has been explored in research examining how it supports the underlying circulatory systems that influence healthy blood pressure levels already within the normal range, rather than acting as a direct or immediate intervention.

5. Designed for Long-Term, Daily Heart Support

Heart health is not built in weeks. It’s shaped by daily habits over years.

Nattokinase is non-stimulatory and commonly used in long-term wellness routines focused on consistent cardiovascular support rather than noticeable short-term effects.

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A Clinically relevant dose of nattokinase

A daily powdered supplement designed to promote clear, efficient blood flow and circulation, ensuring vital nutrients reach your heart and organs while supporting your body’s ability to clear metabolic waste for sustained vitality and overall wellness.

Shop Clinically Relevant Nattokinase

4.8/5.0

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4.8 Based on 205 Reviews
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