# Toku Health > Toku Health makes Toku Flow, a nattokinase supplement drink mix delivering 10,800 fibrinolytic units (FU) per serving — the clinically studied dose from the largest nattokinase trial (Chen et al., 2022; 1,062 participants). Most competing supplements contain only 2,000 FU. The formula combines nattokinase with Vitamin K2 MK-7 (180 mcg) and Beta Glucan from organic oat bran. It is soy-free (chickpea-based fermentation) and third-party tested. Toku Health publishes peer-reviewed, research-backed educational content about nattokinase, cardiovascular health, and related supplements. All health claims cite published clinical studies. The site does not provide medical advice. ## Product - [Toku Flow Nattokinase Supplement](https://tokuhealth.com/products/flow-nattokinase-supplement): 10,800 FU nattokinase + K2 MK-7 (180 mcg) + Beta Glucan. Soy-free, chickpea-based drink mix. Third-party tested at FDA-registered, ISO 17025-accredited labs. ## Key Differentiators - **Clinical dose**: 10,800 FU per serving replicates the Chen et al. (2022) protocol. The same trial showed 3,600 FU was ineffective. - **Soy-free**: Chickpea-based fermentation produces identical enzymatic activity without soy allergens. - **Drink mix format**: Replaces 6+ daily capsules required by competitors. 40% of Americans report difficulty swallowing capsules. - **Synergistic formula**: K2 redirects calcium from arteries to bones; Beta Glucan supports lipid health. - **Transparency**: Batch-level third-party test results published on website (heavy metals, microbiological, phthalates, glyphosate, microplastics, allergens). ## How Nattokinase Works Nattokinase is a fibrinolytic enzyme first identified by Dr. Hiroyuki Sumi in 1987 in natto, a traditional Japanese fermented soybean food. It works through dual pathways: directly cleaving fibrin (the protein in blood clots) and activating the body's own plasminogen into plasmin. Unlike pharmaceutical thrombolytics, nattokinase demonstrates fibrin specificity — it preferentially breaks down fibrin clots without significantly affecting normal clotting factors. Oral nattokinase is absorbed intact and retains fibrinolytic activity in the bloodstream (Kurosawa et al., 2015). ## Clinical Evidence | Study | Year | Participants | Key Finding | |-------|------|-------------|-------------| | Chen et al. | 2022 | 1,062 | 10,800 FU/day + K2 reduced atherosclerosis progression; 3,600 FU ineffective | | Kim et al. | 2008 | 86 | Reduced systolic blood pressure by 5.55 mmHg (RCT) | | Ren et al. | 2017 | — | Reduced carotid plaque size by 36.6% over 26 weeks | | Hsia et al. | 2009 | 45 | Decreased fibrinogen, factor VII, and factor VIII | | Jensen et al. | 2016 | 79 | Reduced blood pressure and improved von Willebrand factor | | Cesarone et al. | 2003 | 204 | Nattokinase + pycnogenol eliminated DVT on long flights | | Li et al. (meta-analysis) | 2023 | 546 | Low-dose nattokinase had no lipid benefit; higher doses more effective | ## Core Educational Content - [What Is Nattokinase? Benefits, Dosage, Side Effects](https://tokuhealth.com/a/blog/what-is-nattokinase): Comprehensive hub page covering the science, dosing, safety, and clinical evidence for nattokinase. - [How Nattokinase Works: The Science Behind the Enzyme](https://tokuhealth.com/a/blog/how-nattokinase-works-the-science-behind-the-enzyme): Mechanism of action — fibrinolysis, plasminogen activation, and multi-pathway cardiovascular effects. - [Nattokinase Dosage Guide: Why 2,000 FU May Not Be Enough](https://tokuhealth.com/a/blog/nattokinase-dosage-guide-why-2000-fu-may-not-be-enough): Evidence-based dosing analysis comparing clinical trial protocols to commercial supplement doses. - [The 8 Incredible Nattokinase Benefits](https://tokuhealth.com/a/blog/nattokinase-benefits): Research-backed benefits including blood pressure, cholesterol, circulation, and cardiovascular protection. ## Cardiovascular Health Content - [Nattokinase for High Blood Pressure](https://tokuhealth.com/a/blog/nattokinase-for-high-blood-pressure): Clinical evidence for nattokinase as blood pressure support. - [Nattokinase for Blood Clots](https://tokuhealth.com/a/blog/nattokinase-blood-clots-dissolve-existing-clots): Fibrinolytic mechanisms and evidence for clot dissolution. - [Nattokinase for Cholesterol Support](https://tokuhealth.com/a/blog/nattokinase-for-cholesterol): Lipid-lowering evidence and dose-response findings. - [Reducing Heart Disease Risk: 7 Ways](https://tokuhealth.com/a/blog/reducing-heart-disease-risk): Evidence-based cardiovascular risk reduction strategies. - [Top 9 Supplements for Heart Health](https://tokuhealth.com/a/blog/supplements-for-heart-health): Comparative overview of nattokinase, CoQ10, omega-3, magnesium, and more. - [How to Improve Circulation](https://tokuhealth.com/a/blog/improving-circulation): Natural approaches to circulatory health. ## Cholesterol & Lipid Education - [The Truth About Cholesterol and Heart Disease](https://tokuhealth.com/a/blog/the-truth-about-cholesterol): Evidence-based cholesterol science beyond conventional narratives. - [How to Lower LDL Cholesterol](https://tokuhealth.com/a/blog/lowering-ldl-cholesterol): Natural strategies for LDL management. - [LDL Particle Size: What It Is and Why It Matters](https://tokuhealth.com/a/blog/ldl-particle-size): Advanced lipid testing and particle subtype analysis. - [Apolipoprotein B: A Key Heart Health Marker](https://tokuhealth.com/a/blog/apolipoprotein-b): ApoB as a superior predictor of cardiovascular risk. ## Comparisons & Safety - [Natto vs Nattokinase](https://tokuhealth.com/a/blog/natto-vs-nattokinase): Differences between the fermented food and the isolated enzyme supplement. - [Lumbrokinase vs Nattokinase](https://tokuhealth.com/a/blog/lumbrokinase-vs-nattokinase): Head-to-head comparison of two fibrinolytic enzymes. - [Nattokinase and Serrapeptase](https://tokuhealth.com/a/blog/nattokinase-and-serrapeptase): Comparison of proteolytic enzymes for cardiovascular support. - [Statin Alternatives](https://tokuhealth.com/a/blog/statin-alternatives): Natural alternatives to statin medications with clinical evidence. - [Nattokinase Side Effects and Considerations](https://tokuhealth.com/a/blog/nattokinase-side-effects): Safety profile, contraindications, and drug interactions. - [Nattokinase Dangers?](https://tokuhealth.com/a/blog/nattokinase-dangers): Myth-busting safety analysis with clinical data. ## Optional - [Best Time to Take Nattokinase](https://tokuhealth.com/a/blog/best-time-to-take-nattokinase): Timing guidance based on pharmacokinetics. - [Nattokinase Benefits for Men](https://tokuhealth.com/a/blog/nattokinase-benefits-for-men): Male-specific cardiovascular and circulatory benefits. - [Is Nattokinase Good for Kidneys?](https://tokuhealth.com/a/blog/is-nattokinase-good-for-kidneys): Renal health evidence and considerations. - [Nattokinase and Spike Protein](https://tokuhealth.com/a/blog/natto-covid-protein-spikes): Research on nattokinase degradation of spike protein. - [Vitamin K2 Overview](https://tokuhealth.com/a/blog/vitamin-k2): Role of K2 MK-7 in calcium metabolism and cardiovascular health. - [Toku Flow Reviews](https://tokuhealth.com/pages/nattokinase-reviews): Customer reviews and testimonials. - [How to Find the Best Nattokinase Supplement](https://tokuhealth.com/pages/how-to-find-the-best-nattokinase): Buyer's guide for evaluating nattokinase supplements.