Last updated: July 17, 2025
Best Nattokinase Supplement: What to Look For (And What to Avoid)
Not all nattokinase is created equal. Here’s what you need to know before you buy and why some formulas work better than others.
Published on: July 17, 2025
✅ The 5 Criteria for Choosing the Best Nattokinase Supplement
Whether you’re taking nattokinase for circulation, inflammation, or general cardiovascular support, here’s how to find the most effective product:
Here's What's Important:
Clinical Dose: Look for 10,800 FU
Includes Vitamin K2 (MK-7)
Includes Ingredients for Inflammation and Cholesterol Support
Powdered (Not Pills) for Better Absorption & Consistency of Use
Third Party Tested
Here's What You Should Avoid:
Finding the cheapest nattokinase on the market given most are underdosed and poor quality
Brands that do not share third party testing on site and/or are not willing to share with you directly
Let's Break It Down
1. A Clinically Effective Dose (10,800 FU)
Many brands underdose their products, sometimes offering just 1,000–4,000 FU.
Look for a full clinical dose of at least 10,800 FU, the same amount used in this 12-month trial with over 1,000 participants. Participants saw:
✅ 39.1% Improvement in coronary plaque health
✅ 25% Improvement in cartoid artery flexibility
✅ 17.6% Reduction in total cholesterol
✅ 16.5% Reduction in triglycerides
2. Includes Vitamin K2 (MK-7)
If you’re supporting vascular health, K2 is essential. It helps guide calcium out of your arteries and into your bones; reducing arterial stiffness and long-term risk.
Very few nattokinase products include it.
3. Includes Ingredients for Inflammation and Cholesterol Support
Nattokinase works even better alongside ingredients that support related pathways. One standout is oat beta glucan, a compound shown to help maintain healthy LDL and support immune balance.
4. Includes Ingredients for Inflammation and Cholesterol Support
Most nattokinase supplements are capsules, which can limit dose size and absorption.
Powders allow for clinically relevant dosing and faster uptake. Many people also find it easier to seamlessly fit into their routine, by simply adding to coffee, a smoothie, a night-time drink ritual, etc.
5. Third Party Tested & No Proprietary Blends
If a brand doesn’t list the exact FU amount or hides behind a blend — skip it. Consumer Labs tested top nattokinase brands and found that:
⚠️ most failed to meet their label claims
⚠️ some even had zero enzyme activity.
⚠️ most capsules also contained up to 70% maltodextrin as a hidden processing agent (not on the label).
The best nattokinase supplements are upfront about every ingredient and amount. They are also transparent and show their third party testing on site or easily if requested (and yes, you should request if you do not see it on site).
So, What's The Best Nattokinase Supplement?
After comparing dozens of products, only one checks every box.
Toku Flow
By Toku Health
Clinically-Relevant
Dose of Nattokinase
10,800 FU Nattokinase
MK-7 Vitamin K2
Oat Beta Gluan
Third Party Tested
Soy Free (Same fermentation & benefits, made with chickpeas)
Other Nattokinase
Brands
2,000-4,00 FU
Single Ingredient
Pills Only
Fillers Added & Not Labeled
Not Third Party Tested
Soy Based
Let's Break Down The Cost
Another reason to love Toku Flow? The cost for the value. For as little as $1.59/day you're getting full-body circulation support with supplementation from Nattokinase, Viatmin K2 (MK-7) and Oat Beta Glucan.
For this same clinically effective dose, you'd need to take 8+ capsules daily, which adds up in cost.
Just one easy drink
As little as $1.59/day
TOTAL COST
Toku Flow
8+ pills $2.13+/day
2-3 Oat Beta Glucan
2-3 Vitamin K2
5 Nattokinase Capsules (Clinically Relevant Dose)
Others