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Nattokinase and Serrapeptase
In recent years, nattokinase and serrapeptase have gained attention for their potential to support cardiovascular health, reduce inflammation, and support better circulation. These two proteolytic enzymes, derived from natural sources, are often used individually or in combination as dietary supplements. While they are not pharmaceuticals and lack approval from regulatory bodies like the FDA for treating specific medical conditions, numerous studies and anecdotal reports suggest they offer meaningful benefits when used appropriately. This post explores their sources, mechanisms, benefits, and more.
What Is Nattokinase?
Nattokinase is a potent fibrinolytic enzyme extracted from natto, a traditional Japanese food made from fermented soybeans using the bacterium bacillus subtilis natto. The fermentation process produces this enzyme, which has the unique ability to break down fibrin, the protein responsible for blood clot formation.
First isolated and studied in the 1980s by Japanese researcher Dr. Hiroyuki Sumi, nattokinase has been the subject of multiple clinical trials. Published research has demonstrated that nattokinase can help maintain healthy blood pressure levels, improve blood flow, and support the body's natural clot-dissolving processes. A meta-analysis of randomized controlled trials confirmed that daily nattokinase supplementation significantly reduced both systolic and diastolic blood pressure.
Beyond blood pressure management, nattokinase shows promise in supporting overall cardiovascular health by reducing arterial plaque buildup and improving vascular elasticity. It works directly in the bloodstream for several hours after ingestion, making it a valuable natural alternative or complementary option for those concerned about heart health.
Toku Flow is a daily supplement from Toku Health with 10,800 FU for natural, multi-functional cardiovascular support. It combines nattokinase with vitamin K2 and beta-glucan to support balanced cholesterol, optimal blood pressure, and more without the side effects of pharmaceuticals.
What Is Serrapeptase?
Serrapeptase, also known as serratiopeptidase, is a proteolytic enzyme originally isolated from the bacterium serratia marcescens found in the digestive tract of silkworms. The enzyme helps silkworms dissolve their cocoons by breaking down proteins, and when harvested for human use, it retains powerful protein-degrading capabilities.
Introduced as a supplement in Japan and Europe decades ago, serrapeptase is widely recognized for its strong anti-inflammatory and pain-relieving properties. Clinical studies have shown benefits of serrapeptase including reduce post-operative swelling, alleviate chronic sinusitis symptoms, and help manage conditions involving excess mucus or scar tissue formation.
Serrapeptase works systemically by breaking down non-living proteins such as fibrin, dead tissue, and inflammatory byproducts without harming healthy living tissue. This selective action makes it particularly useful for reducing chronic inflammation associated with atherosclerosis, fibromyalgia, and respiratory conditions.
Synergistic Benefits of Combining Nattokinase and Serrapeptase
Many practitioners and supplement manufacturers combine serrapeptase with a nattokinase supplement because their mechanisms complement each other exceptionally well. Nattokinase primarily targets fibrin in the bloodstream to prevent excessive clotting, while serrapeptase excels at clearing fibrin and inflammatory debris from tissues and arterial walls.
A growing number of users report improved circulation, reduced joint stiffness, and better breathing when taking both enzymes together.
Safety Profile and Precautions
Both enzymes are generally well-tolerated when taken as directed. Large-scale studies in Japan, where nattokinase has been consumed for decades, show an excellent safety record. Serrapeptase has been used medically in Asia and Europe for over 40 years with minimal adverse effects.
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High-Potency Nattokinase Supplement for Cardiovascular Health & CirculationToku Flow delivers 10,800 FU of clinical-grade nattokinase per daily sachet, paired with Vitamin K2 (MK-7) and oat beta-glucan for comprehensive cardiovascular support. Sourced from chickpea fermentation (soy-free), third-party tested, no fillers.… read more
Bottom Line
Nattokinase and serrapeptase represent two of nature's most impressive enzymes for supporting cardiovascular health and reducing chronic inflammation. Backed by decades of research and traditional use, they offer a natural approach that many people find effective as part of a comprehensive wellness routine.
While they are not substitutes for medical treatment or lifestyle changes—healthy diet, exercise, and stress management remain fundamental—these enzymes can play a valuable complementary role for those who seek to improve circulation and optimize cardiovascular health naturally.
Always choose high-quality, third-party tested supplements and work with a knowledgeable healthcare practitioner to determine if nattokinase, serrapeptase, or a combination of both is best for you.
